Publicēti raksti (MF) / Published Articles
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Browsing Publicēti raksti (MF) / Published Articles by Author "Erglis, Andrejs"
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- ItemAtherosclerotic Plaque Characteristics by CT Angiography Identify Coronary Lesions That Cause Ischemia A Direct Comparison to Fractional Flow Reserve(Elsevier, 2015) Park, Hyung-Bok; Heo, Ran; Hartaigh, Bríain; Cho, Iksung; Gransar, Heidi; Nakazato, Ryo; Leipsic, Jonathon; Mancini, John; Koo, Bon-Kwon; Otake, Hiromasa; Budoff, Matthew J.; Berman, Daniel S.; Erglis, Andrejs; Chang, Hyuk-Jae; Min, James K.
- ItemA common promoter variant of the gene encoding cyclooxygenase-1 (PTGS1) is related to decreased incidence ofmyocardial infarction in patients with coronary artery disease(Elsevier, 2011) Latkovskis, Gustavs; Licis, Normunds; Krivmane, Baiba; Erglis, AndrejsCyclooxigenase (COX)-1, formally known as prostanglandin endoperoxideH synthetase-1,mediates synthesis of prostaglandin H2,which is subsequently converted to various biologically active metabolites including thromboxane (TX) A2 [1]. TXA2 is synthesized and released by activated platelets and strongly reinforces thrombus formation, a critical pathway in the pathogenesis of myocardial infarction (MI). Inhibition of COX-1-derived TXA2 in platelets by low-dose aspirin administration reduces incidence of MI [2]. Hypothetically, MI-risk could also be modified by genetic variants that affect activity or expression of COX-1. Many single nucleotide polymorphisms (SNP) in the gene encoding COX-1 (PTGS1) have been described; including functional alterations in both coding and non-coding regions [3,4].We have evaluated if two of such variations are related to the risk ofMI in a historic cohort of patients with coronary artery disease (CAD).
- ItemPrevalence estimation of celiac disease in the general adult population of Latvia using serology and HLA genotyping(Sage, 2015) Leja, Marcis; Shums, Zakera; Nikitina-Zake, Liene; Gavars, Mikus; Kikuste, Ilze; Milo, Jay; Pahomova, Jelena; Pirags, Valdis; Dzerve, Vilnis; Klovins, Janis; Erglis, Andrejs; Norman, Gary L.