Evaluation of Physicochemical Properties of Amphiphilic 1,4-Dihydropyridines and Preparation of Magnetoliposomes

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dc.contributor.authorPetrichenko, Oksana
dc.contributor.authorPlotniece, Aiva
dc.contributor.authorPajuste, Karlis
dc.contributor.authorRucins, Martins
dc.contributor.authorDmitrijevs, Pavels
dc.contributor.authorSobolev, Arkadij
dc.contributor.authorSprugis, Einars
dc.contributor.authorCebers, Andrejs
dc.date.accessioned2021-08-26T07:34:04Z
dc.date.available2021-08-26T07:34:04Z
dc.date.issued2021
dc.descriptionThis work was financially supported by PostDocLatvia Project No 1.1.1.2/VIAA/1/16/018 (O. Petrichenko: TGA and DTA analysis, magnetic nanoparticles synthesis, preparation and characterization of magnetoliposomes), PostDocLatvia Project No 1.1.1.2/VIAA/2/18/371 (M. Rucins:synthesis and characterization of 1,4-DHP amphiphiles), LIOS internal grant IG-2018-13 (P. Dimitrijevs: LB measurements) and M.era-net project FMF No.1.1.1.5/ERANET/18/04; Institute of Solid State Physics, University of Latvia as the Center of Excellence has received funding from the European Union’s Horizon 2020 Framework Programme H2020-WIDESPREAD-01-2016-2017-TeamingPhase2 under grant agreement No. 739508, project CAMART²en_US
dc.description.abstractThis study was focused on the estimation of the targeted modification of 1,4-DHP core with (1) different alkyl chain lengths at 3,5-ester moieties of 1,4-DHP (C12, C14 and C16); (2) N-substituent at position 1 of 1,4-DHP (N-H or N-CH3); (3) substituents of pyridinium moieties at positions 2 and 6 of 1,4-DHP (H, 4-CN and 3-Ph); (4) substituent at position 4 of 1,4-DHP (phenyl and napthyl) on physicochemical properties of the entire molecules and on the characteristics of the obtained magnetoliposomes formed by them. It was shown that thermal behavior of the tested 1,4-DHP amphiphiles was related to the alkyl chains length, the elongation of which decreased their transition temperatures. The properties of 1,4-DHP amphiphile monolayers and their polar head areas were determined. The packing parameters of amphiphiles were in the 0.43–0.55 range. It was demonstrated that the structure of 1,4-DHPs affected the physicochemical properties of compounds. “Empty” liposomes and magnetoliposomes were prepared from selected 1,4-DHP amphiphiles. It was shown that the variation of alkyl chains length or the change of substituents at positions 4 of 1,4-DHP did not show a significant influence on properties of liposomes.---//---This work is licensed under a CC BY 4.0 license.en_US
dc.description.sponsorshipPostDocLatvia Project No 1.1.1.2/VIAA/1/16/018; PostDocLatvia Project No 1.1.1.2/VIAA/2/18/37; LIOS internal grant IG-2018-13; M.era-net project FMF No.1.1.1.5/ERANET/18/04; Institute of Solid State Physics, University of Latvia as the Center of Excellence has received funding from the European Union’s Horizon 2020 Framework Programme H2020-WIDESPREAD-01-2016-2017-TeamingPhase2 under grant agreement No. 739508, project CAMART²en_US
dc.identifier.doi10.3390/nano11030593
dc.identifier.issn2079-4991
dc.identifier.urihttps://www.mdpi.com/2079-4991/11/3/593
dc.identifier.urihttps://dspace.lu.lv/dspace/handle/7/56485
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/739508/EU/Centre of Advanced Material Research and Technology Transfer/CAMART²en_US
dc.relation.ispartofseriesNanomaterials;11(3), 593
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.licenseCC BY 4.0 license
dc.subjectResearch Subject Categories::NATURAL SCIENCES:Physicsen_US
dc.subject1,4-dihydropyridine amphiphilesen_US
dc.subjectiron oxide nanoparticlesen_US
dc.subjectmagnetoliposomesen_US
dc.subjectlipid monolayersen_US
dc.subjectphysicochemical propertiesen_US
dc.titleEvaluation of Physicochemical Properties of Amphiphilic 1,4-Dihydropyridines and Preparation of Magnetoliposomesen_US
dc.typeinfo:eu-repo/semantics/articleen_US
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