1,2-benzoksatiīn-2,2-dioksīda atvasinājumi un to heterocikliskie analogi kā selektīvi ogļskābes anhidrāžu inhibitori
Date
2016
Authors
Grandāne, Aiga
Journal Title
Journal ISSN
Volume Title
Publisher
Latvijas Universitāte
Abstract
1,2-benzoksatiīn-2,2-dioksīda atvasinājumi un to heterocikliskie analogi kā selektīvi ogļskābes anhidrāžu inhibitori. Grandāne A., zinātniskais vadītājs Dr. chem. Žalubovskis R. Promocijas darbs, 213 lapas, 151 attēls, 39 tabulas, 164 literatūras avoti. Latviešu valodā. Promocijas darba izstrādes gaitā ir atrasta jauna selektīva CA IX un CA XII inhibitoru klase – 1,2-benzoksatiīn-2,2-dioksīdi 1. Izstrādātas šo savienojumu iegūšanas metodes, kā arī iegūti 3-, 4-, 5-, 6-, 7- un 8-aizvietoti atvasinājumi. Izstrādātas sintēzes metodes jaunām, līdz šim literatūrā nezināmām savienojumu klasēm - tiēno[2,3-e][1,2]oksatiīn-2,2-dioksīdiem 2 un [1,2]oksatiīn[6,5-b]piridīn-2,2- dioksīdiem 3 -, kā arī izpētītas šo savienojumu klašu atvasināšanas iespējas. 1,2-OKSATIĪN-2,2-DIOKSĪDS, BIOIZOSTĒRS, OGĻSKĀBES ANHIDRĀZES, INHIBITORI.
Derivatives of 1,2-benzoxathiine 2,2-dioxide and their heterocyclic analogues as selective inhibitors of carbonic anhydrases. Grandāne A., scientific supervisor Dr. chem. Žalubovskis R. Doctoral thesis, 213 pages, 151 figures, 39 tables, 164 literature referencess. In Latvian. During the work on doctoral thesis a new selective inhibitor class of CA IX and CA XII – 1,2-benzoxathiine 2,2-dioxides 1 has been discovered. Methods of 1,2- benzoxathiine 2,2-dioxides synthesis were developed. Methods of synthesis of thieno[2,3-e][1,2]oxathiine 2,2-dioxides 2 and [1,2]oxathiino[6,5-b]pyridine 2,2- dioxides 3 which are new, in literature unknown classes of compounds, were developed, as well as a research of derivatization of these classes was carried out. 1,2-OXATHIINE 2,2-DIOXIDE, BIOISOSTERE, CARBONIC ANHYDRASES, INHIBITORS.
Derivatives of 1,2-benzoxathiine 2,2-dioxide and their heterocyclic analogues as selective inhibitors of carbonic anhydrases. Grandāne A., scientific supervisor Dr. chem. Žalubovskis R. Doctoral thesis, 213 pages, 151 figures, 39 tables, 164 literature referencess. In Latvian. During the work on doctoral thesis a new selective inhibitor class of CA IX and CA XII – 1,2-benzoxathiine 2,2-dioxides 1 has been discovered. Methods of 1,2- benzoxathiine 2,2-dioxides synthesis were developed. Methods of synthesis of thieno[2,3-e][1,2]oxathiine 2,2-dioxides 2 and [1,2]oxathiino[6,5-b]pyridine 2,2- dioxides 3 which are new, in literature unknown classes of compounds, were developed, as well as a research of derivatization of these classes was carried out. 1,2-OXATHIINE 2,2-DIOXIDE, BIOISOSTERE, CARBONIC ANHYDRASES, INHIBITORS.
Description
Elektroniskā versija nesatur pielikumus
Keywords
Ķīmija , Ķīmija, ķīmijas tehnoloģijas un biotehnoloģija