Poor optical stability of molecular dyes when used as absorbers in water-based tissue-simulating phantoms

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dc.contributor.authorCugmas, Blaž
dc.contributor.authorNaglič, Peter
dc.contributor.authorMenachery, Sunil Paul Matthew
dc.contributor.authorPernuš, Franjo
dc.contributor.authorLikar, Boštjan
dc.date.accessioned2019-04-30T07:29:41Z
dc.date.available2019-04-30T07:29:41Z
dc.date.issued2019-02-27
dc.description.abstractBiomedical optical systems and models can be easily validated by the use of tissue-simulating phantoms. They can consist of water-based turbid media which often include inks (India ink and molecular dyes) as absorbers. Optical stability of commonly exploited inks under the influence of light, pH changes and the addition of TiO2 and surfactant, was studied. We found that the exposure to ultraviolet and visible light can crucially affect the absorption properties of molecular dyes. On average, absorption peaks decreased by 47.3% in 150 exposure hours. Furthermore, dilution can affect ink’s pH and by that, its decay rate under light exposure. When TiO2 was added to the phantoms, all molecular dyes decayed rapidly. Photocatalytic nature of TiO2 can be partially avoided by selecting TiO2 with surface and crystal structure modification. Surfactant, normally present in the phantoms with polystyrene spheres, can cause absorption peak shifts up to 20 nm and amplitude changes of 29.6%. Therefore, it is crucial to test the optical stability of inks in the presented manner before their exploitation in water-based phantoms.en_US
dc.description.sponsorshipEU_MSCA_IF_DogSpec_745396en_US
dc.identifier.citationBlaž Cugmas, Peter Naglič, Sunil Paul Matthew Menachery, Franjo Pernuš, Boštjan Likar, "Poor optical stability of molecular dyes when used as absorbers in water-based tissue-simulating phantoms," Proc. SPIE 10870, Design and Quality for Biomedical Technologies XII, 108700N (27 February 2019); doi: 10.1117/12.2506977en_US
dc.identifier.doi10.1117/12.2506977
dc.identifier.urihttps://dspace.lu.lv/dspace/handle/7/46615
dc.language.isoengen_US
dc.publisherSPIEen_US
dc.relationEU_MSCA_IF_DogSpec_745396en_US
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/745396/ EU/ Multimodal Spectral Imaging for Canine Skin Erythema Estimation: from the Lab to the Clinic/DogSPEC
dc.relation.ispartofseriesProc. SPIE;10870
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecttissue-simulating phantomsen_US
dc.subjectturbid mediaen_US
dc.subjectmolecular dyesen_US
dc.subjectoptical spectroscopyen_US
dc.subjectoptical stabilityen_US
dc.subjectIndia inken_US
dc.subjectsurfactanten_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Physics::Atomic and molecular physicsen_US
dc.titlePoor optical stability of molecular dyes when used as absorbers in water-based tissue-simulating phantomsen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
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