Carnitine congener mildronate protects against stress- and haloperidol-induced impairment in memory and brain protein expression in rats

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dc.contributor.authorBeitnere, Ulrika
dc.contributor.authorDzirkale, Zane
dc.contributor.authorIsajevs, Sergejs
dc.contributor.authorRumaks, Juris
dc.contributor.authorSvirskis, Simons
dc.contributor.authorKlusa, Vija
dc.date.accessioned2015-12-02T19:27:19Z
dc.date.available2015-12-02T19:27:19Z
dc.date.issued2014
dc.description.abstractThe present study investigates the efficacy of mildronate, a carnitine congener, to protect stress and haloperidol-induced impairment of memory in rats and the expression of brain protein biomarkers involved in synaptic plasticity, such as brain-derived neurotrophic factor (BDNF), acetylcholine esterase and glutamate decarboxylase 67 (GAD67). Two amnesia models were used: 2 h immobilization stress and 3-week haloperidol treatment. Stress caused memory impairment in the passive avoidance test and induced a significant 2-fold BDNF elevation in hippocampal and striatal tissues that was completely inhibited by mildronate. Mildronate decreased the level of GAD67 (but not acetylcholine esterase) expression by stress. Haloperidol decrease by a third hippocampal BDNF and acetylcholine esterase (but not GAD67) expression, which was normalized by mildronate; it also reversed the haloperidol-induced memory impairment in Barnes test. The results suggest the usefulness of mildronate as protector against neuronal disturbances caused by stress or haloperidol.en_US
dc.identifier.doi10.1016/j.ejphar.2014.10.014
dc.identifier.urihttps://dspace.lu.lv/dspace/handle/7/31261
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesEuropean Journal of Pharmacology;vol. 745
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.subjectStressen_US
dc.subjectHaloperidolen_US
dc.subjectMemoryen_US
dc.subjectProteinexpressionen_US
dc.subjectMildronateen_US
dc.titleCarnitine congener mildronate protects against stress- and haloperidol-induced impairment in memory and brain protein expression in ratsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
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