γ1- and γ2-melanocyte stimulating hormones induce central anxiogenic effects and potentiate ethanol withdrawal responses in the elevated plus-maze test in mice

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dc.contributor.authorJansone, Baiba
dc.contributor.authorRumaks, Juris
dc.contributor.authorDzirkale, Zane
dc.contributor.authorPupure, Jolanta
dc.contributor.authorSvirskis, Šimons
dc.contributor.authorMuceniece, Ruta
dc.contributor.authorKlusa, Vija
dc.date.accessioned2015-12-02T15:58:27Z
dc.date.available2015-12-02T15:58:27Z
dc.date.issued2009
dc.description.abstractLittle is known about the endogenous functions of γ1- and γ2-melanocyte stimulating hormones (γ1- and γ2-MSH). Although γ-MSHs bind to melanocortin receptor subtypes 3 and 4, we have previously shown that these peptides also influence non-melanocortinergic processes, such as dopaminergic and GABAergic. The aim of this study was to determine the effects of γ1- and γ2-MSH (at doses 0.3, 1 and 2 nmol/mouse/5 μl) on the anxiety levels in mice in elevated plus maze. Three experimental paradigms were performed to assess the effects of peptides on: a) ethanol withdrawal; b) acute ethanol-induced anxiolytic action; c) peptides per se. We used ethanol as the model substance, since its action involves either dopaminergic/GABAergic or melanocortinergic processes. γ-MSHs were administered intracisternally in mice and behavioural responses were assessed in the elevated plus maze test. This study provides the first demonstration of an anxiogenic effect of γ1- and γ2-MSH, their synergistic/additive effect on ethanol withdrawal-induced anxiety behaviour, and an antagonism of peptides involved in the anxiolytic action of ethanol. Furthermore, results suggest that γ-MSHs belong to an anxiogenic peptide family that may play an important role in anxiety disorders as well as in the development of alcohol dependence and/or alcohol withdrawal-induced behaviours.en_US
dc.identifier.doi10.1016/j.pbb.2008.12.008
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0091305708004036
dc.identifier.urihttps://dspace.lu.lv/dspace/handle/7/31260
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesPharmacology, Biochemistry and Behavior;Vol. 92
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.subjectγ1-MSHen_US
dc.subjectγ2-MSHen_US
dc.subjectAnxietyen_US
dc.subjectEthanol withdrawal responsesen_US
dc.subjectElevated plus-maze testen_US
dc.titleγ1- and γ2-melanocyte stimulating hormones induce central anxiogenic effects and potentiate ethanol withdrawal responses in the elevated plus-maze test in miceen_US
dc.typeinfo:eu-repo/semantics/articleen_US
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