Droperidola kristālisko formu iegūšana un struktūra
Date
2006
Authors
Orola, Liāna
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Journal ISSN
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Publisher
Latvijas Universitāte
Abstract
Darbā ir noteikta droperidola x un z modifikācijas kristāliskā struktūra, izmantojot monokristāla rentgenstruktūranalīzi. Droperidola x modifikācijas kristāli pieder pie triklīnās singonijas: Pī; a=6,2842(15) Å; b=10,1473(8) Å; c=16,1850(2) Å; α=102,554(9) º; β=91,917(14) º; γ=99,316(12) º; V=991,6(3) Å3; Z=2; ρc=1,30 g/cm3; λ(Cu Kα)=1,5418 Å; μ=0,760 mm-1, R=0,045. Droperidola z modifikācija kristalizējas monoklīnā singonijā: P21/c; a=20,0406(8) Å; b=7,4955(4) Å; c=12,9733(5) Å; β=98,089(2) º; V=1929,39(15) Å3; Z=4; ρc=1,306 g/cm3; λ(Mo Kα)=0,71073 Å; μ=0,092 cm-1, R=0,048. Abu modifikāciju molekulas veido divas N–HņņņO ūdeņraža saites.
In this study crystal structures of x and z polymorphs of droperidol have been determined using X-ray diffraction analysis of a single crystals. Droperidol x polymorph crystal is triclinic, space group Pī, with a=6,2842(15) Å; b=10,1473(8) Å; c=16,1850(2) Å; α=102,554(9) º; β=91,917(14) º; γ=99,316(12) º; V=991,6(3) Å3; Z=2; ρc=1,30 g/cm3; λ(Cu Kα)=1,5418 Å; μ=0,760 mm-1, R=0,045. Droperidol z polymorph crystals is monoclinic, space group P21/c; a=20,0406(8) Å; b=7,4955(4) Å; c=12,9733(5) Å; β=98,089(2) º; V=1929,39(15) Å3; Z=4; ρc=1,306 g/cm3; λ(Mo Kα)=0,71073 Å; μ=0,092 cm-1, R=0,048. Both polymorph molecules form two N–HņņņO hydrogen bonds.
In this study crystal structures of x and z polymorphs of droperidol have been determined using X-ray diffraction analysis of a single crystals. Droperidol x polymorph crystal is triclinic, space group Pī, with a=6,2842(15) Å; b=10,1473(8) Å; c=16,1850(2) Å; α=102,554(9) º; β=91,917(14) º; γ=99,316(12) º; V=991,6(3) Å3; Z=2; ρc=1,30 g/cm3; λ(Cu Kα)=1,5418 Å; μ=0,760 mm-1, R=0,045. Droperidol z polymorph crystals is monoclinic, space group P21/c; a=20,0406(8) Å; b=7,4955(4) Å; c=12,9733(5) Å; β=98,089(2) º; V=1929,39(15) Å3; Z=4; ρc=1,306 g/cm3; λ(Mo Kα)=0,71073 Å; μ=0,092 cm-1, R=0,048. Both polymorph molecules form two N–HņņņO hydrogen bonds.
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