Skābekļa ekstrakcijas efektivitāte fiziskas slodzes apstākļos akūtā hipoksijā
Date
2009
Authors
Āboliņš, Andris
Journal Title
Journal ISSN
Volume Title
Publisher
Latvijas Universitāte
Abstract
Galvenais darba mērķis ir raksturot organisma O2 patēriņa fizioloģisko nodrošinājumu normobāriskos akūtas hipoksijas apstākļos, kad tiek veikta fiziska slodze. Lai šo mērķi sasniegtu, tika mērīti dažādi fizioloģiskie parametri - hemoglobīna skābekļa piesātinājums (oksimetrs), hemoglobīna koncentrācija (laboratorijā), plaušu ventilācija un tās raksturlielumi – elpošanas frekvence un tilpums (metabometrs), sirds minūtes tilpums (finometrs) un patērētais skābeklis (metabometrs).
Pētījuma gaitā noskaidrots, ka hipoksijā daudz zemāks ir hemoglobīna skābekļa saturs arteriālajās asinīs, zemāka ir arī hemoglobīna koncentrācija attiecībā pret tādu pašu fizisko slodzi vai miera stāvokli normoksijā. Hipoksijā, attiecībā pret normoksiju, palielinās plaušu ventilācija un elpošanas tilpums, palielinās arī sirds minūtes tilpums.
Pēc skābekļa patēriņa un sirds minūtes tilpumu attiecības var noteikt skābekļa ekstrakcijas efektivitāti fiziskā slodzē vai arī miera apstākļos.
Darbs izstrādāts laika periodā no 2008.gada 24.februāra līdz 22.aprīlim Latvijas Universitātes Bioloģijas fakultātes Cilvēku un dzīvnieku fizioloģijas katedrā.
Atslēgas vārdi: normoksija, akūta normobāriska hipoksija, skābekļa ekstrakcija, veloergometriska slodze
The main goal of the bachelor thesis is to describe the physiological provision of body’s oxygen consumption in conditions of acute hypoxia during physical exercise. In order to reach this goal, different physiological parameters were measured – the saturation of hemoglobin’s oxygen (by oximeter), concentration of hemoglobin (in laboratory), pulmonary ventilation and its characteristics – respiratory rate and tidal volume (by MedGraphics VO2000), cardiac output (by finometer) and consumed oxygen (by MedGraphics VO2000). During the research work it is found out that the saturation of hemoglobin’s oxygen is much lower in conditions of hypoxia as well as the concentration of hemoglobin is lower compared to the same physical exercise or steady state in conditions of normoxia. It is possible to estimate effectiveness of oxygen extraction during physical exercise or steady state by the proportion of oxygen consumption and cardiac output. The experimental protocol has been done from 24th February, 2009 till 22nd April, 2009 in University of Latvia, Biology Faculty Department of Human and Animal Physiology. Key words: normoxia, acute normobaric hypoxia, oxygen extraction, veloergometric exercise
The main goal of the bachelor thesis is to describe the physiological provision of body’s oxygen consumption in conditions of acute hypoxia during physical exercise. In order to reach this goal, different physiological parameters were measured – the saturation of hemoglobin’s oxygen (by oximeter), concentration of hemoglobin (in laboratory), pulmonary ventilation and its characteristics – respiratory rate and tidal volume (by MedGraphics VO2000), cardiac output (by finometer) and consumed oxygen (by MedGraphics VO2000). During the research work it is found out that the saturation of hemoglobin’s oxygen is much lower in conditions of hypoxia as well as the concentration of hemoglobin is lower compared to the same physical exercise or steady state in conditions of normoxia. It is possible to estimate effectiveness of oxygen extraction during physical exercise or steady state by the proportion of oxygen consumption and cardiac output. The experimental protocol has been done from 24th February, 2009 till 22nd April, 2009 in University of Latvia, Biology Faculty Department of Human and Animal Physiology. Key words: normoxia, acute normobaric hypoxia, oxygen extraction, veloergometric exercise
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Bioloģija