Lunasin-induced behavioural effects in mice: Focus on the dopaminergic system

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dc.contributor.authorDzirkale, Zane
dc.contributor.authorRumaks, Juris
dc.contributor.authorSvirskis, Simons
dc.contributor.authorMazina, Olga
dc.contributor.authorAllikalt, Anni
dc.contributor.authorRinken, Ago
dc.contributor.authorJekabsons, Kaspars
dc.contributor.authorMuceniece, Ruta
dc.contributor.authorKlusa, Vija
dc.date.accessioned2015-12-02T20:45:06Z
dc.date.available2015-12-02T20:45:06Z
dc.date.issued2013
dc.description.abstractThe present study for the first time is devoted to identify central effects of synthetic lunasin, a 43 amino acid peptide. A markedly expressed neuroleptic/cataleptic effect was observed at low (0.1–10 nmol/mouse) centrally administered doses in male C57Bl/6 mice. Lunasin considerably reduced the amphetamine hyperlocomotion but weakly apomorphine climbing behaviour. No influence on ketamine and bicuculline effects was observed. Binding assay studies demonstrated modest affinity of lunasin for the dopamine D1 receptor (Ki = 60±15 M). In a functional assay of cAMP accumulation on live cells lunasin antagonised apomorphine effect on D1 receptor activation (pEC50 = 6.1±0.3), but had no effect in cells expressing D2 receptors. The obtained data suggest that lunasin’s action at least in part is provided via dopaminergic D1 receptor pathways. However, other non-identified mechanisms (probably intracellular) may play an important role in lunasin’s central action. Nevertheless further studies of lunasin are promising, particularly taking into account a necessity for novel type of antipsychotic drugsen_US
dc.identifier.doi10.1016/j.bbr.2013.08.002
dc.identifier.urihttps://dspace.lu.lv/dspace/handle/7/31269
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesBehavioural Brain Research;vol.256
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectLunasinen_US
dc.subjectBehaviouren_US
dc.subjectDopamine receptorsen_US
dc.subjectcAMPen_US
dc.titleLunasin-induced behavioural effects in mice: Focus on the dopaminergic systemen_US
dc.typeinfo:eu-repo/semantics/articleen_US
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