Amfifīlu 1,4-dihidropiridīna atvasinājumu 2,6-vietu modificēšana un to pašasociējošo īpašību pētījumi
Date
2017
Authors
Ragže, Jēkabs
Journal Title
Journal ISSN
Volume Title
Publisher
Latvijas Universitāte
Abstract
Amfifīlu 1,4-dihidropiridīna atvasinājumu 2,6-vietu modificēšana un to pašasociējošo īpašību pētījumi. Ragže J., darba vadītājs Dr.chem., vadošais pētnieks Pajuste K. Bakalaura darbs, 46 lappuses, 10 attēli, 5 tabulas, 59 literatūras avoti, 1 pielikums. Latviešu valodā. Raksturota šķīdinātāja ietekme “klika” reakcijai ar didodecil 2,6-bis(azidometil)-4-fenil-1,4-dihidropiridīna-3,5-dikarboksilātu. Sintezēti pieci jauni kandidātsavienojumi gēnu terapijai, aizvietojot bromu didodecil 2,6-bis((4-(brommetil)-1H-1,2,3-triazol-1-il)metil)-4-fenil-1,4-dihidropiridīna-3,5-dikarboksilātā ar dažādiem piridīniem. Noteikta kritiskā micellu koncentrācija, izmantojot dinamiskās gaismas izkliedes metodi. Noskaidrots, ka 3-metil-, 4-metil- aizvietoti un neaizvietoti savienojumi pie piridīnija cikla uzrāda zemāku kritisko micellu koncentrāciju nekā savienojumi bez triazola cikla.
Derivatization of 1,4-dihydropyridines at 2,6-position and studies of their self-assembling properties. Ragže J., supervisor Dr.chem., principal scientist Pajuste K. Bachelor’s thesis, 46 pages, 10 figures, 5 tables, 59 literature references, 1 appendix. In Latvian. Solvent influence on click reaction with didodecyl 2,6-bis(azidomethyl)-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate has been studied. Five new gene therapy candidates have been synthesised from didodecyl 2,6-bis((4-(bromomethyl)-1H-1,2,3-triazol-1-yl)methyl)-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate by substitution of bromine with various pyridines. Dynamic light scattering method has been used to determine critical micelle concentration. 3-Methyl, 4-methyl substituted and unsubstituted pyridinium compounds have been found to have lower critical micelle concentrations than analogues which do not have triazole heterocycle as spacer.
Derivatization of 1,4-dihydropyridines at 2,6-position and studies of their self-assembling properties. Ragže J., supervisor Dr.chem., principal scientist Pajuste K. Bachelor’s thesis, 46 pages, 10 figures, 5 tables, 59 literature references, 1 appendix. In Latvian. Solvent influence on click reaction with didodecyl 2,6-bis(azidomethyl)-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate has been studied. Five new gene therapy candidates have been synthesised from didodecyl 2,6-bis((4-(bromomethyl)-1H-1,2,3-triazol-1-yl)methyl)-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate by substitution of bromine with various pyridines. Dynamic light scattering method has been used to determine critical micelle concentration. 3-Methyl, 4-methyl substituted and unsubstituted pyridinium compounds have been found to have lower critical micelle concentrations than analogues which do not have triazole heterocycle as spacer.
Description
Keywords
Ķīmija , 1,4-DIHIDROPIRIDĪNI , KLIKA REAKCIJA , AMFIFILI , PIRIDĪNIJI , KRITISKĀ MICELLU KONCENTRĀCIJA