Intranasal Administration of Extracellular Vesicles Derived from Human Teeth Stem Cells Improves Motor Symptoms and Normalizes Tyrosine Hydroxylase Expression in the Substantia Nigra and Striatum of the 6-Hydroxydopamine-Treated Rats

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dc.contributor.authorNarbute, Karīna
dc.contributor.authorPiļipenko, Vladimirs
dc.contributor.authorPupure, Jolanta
dc.contributor.authorDzirkale, Zane
dc.contributor.authorJonavičė, Ugnė
dc.contributor.authorTunaitis, Virginijus
dc.contributor.authorKriaučiūnaitė, Karolina
dc.contributor.authorJarmalavičiūtė, Akvilė
dc.contributor.authorJansone, Baiba
dc.contributor.authorKluša, Vija
dc.contributor.authorPivoriūnas, Augustas
dc.date.accessioned2019-12-04T06:53:15Z
dc.date.available2019-12-04T06:53:15Z
dc.date.issued2019-04-22
dc.description.abstractParkinson's disease (PD) is the second most common neurodegenerative disorder affecting millions of people worldwide. At present, there is no effective cure for PD; treatments are symptomatic and do not halt progression of neurodegeneration. Extracellular vesicles (EVs) can cross the blood–brain barrier and represent promising alternative to the classical treatment strategies. In the present study, we examined therapeutic effects of intranasal administration of EVs derived from human exfoliated deciduous teeth stem cells (SHEDs) on unilateral 6‐hydroxydopamine (6‐OHDA) medial forebrain bundle (MFB) rat model of PD. CatWalk gait tests revealed that EVs effectively suppressed 6‐OHDA‐induced gait impairments. All tested gait parameters (stand, stride length, step cycle, and duty cycle) were significantly improved in EV‐treated animals when compared with 6‐OHDA‐lesion group rats. Furthermore, EVs slowed down numbers of 6‐OHDA‐induced contralateral rotations in apomorphine test. Improvements in motor function correlated with normalization of tyrosine hydroxylase expression in the striatum and substantia nigra. In conclusion, we demonstrated, for the first time, the therapeutic efficacy of intranasal administration of EVs derived from SHEDs in a rat model of PD induced by 6‐OHDA intra‐MFB lesion. Our findings could be potentially exploited for the development of new treatment strategies against PD.en_US
dc.identifier.doi10.1002/sctm.18-0162
dc.identifier.issn2157-6564
dc.identifier.urihttps://dspace.lu.lv/dspace/handle/7/49033
dc.language.isoengen_US
dc.publisherAlphaMed Press Wileyen_US
dc.relation.ispartofseriesStem Cells Translational Journals;Vol. 8, N 5
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdult stem cellsen_US
dc.subjectAnimal modelsen_US
dc.subjectCell signalingen_US
dc.subjectCellular therapyen_US
dc.subjectDifferentiationen_US
dc.subjectParkinson's diseaseen_US
dc.subjectMesenchymal stem cellsen_US
dc.subjectResearch Subject Categories::MEDICINE::Physiology and pharmacology::Pharmacological researchen_US
dc.titleIntranasal Administration of Extracellular Vesicles Derived from Human Teeth Stem Cells Improves Motor Symptoms and Normalizes Tyrosine Hydroxylase Expression in the Substantia Nigra and Striatum of the 6-Hydroxydopamine-Treated Ratsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
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