Association of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients
Date
2013
Authors
Skapare, Elina
Konrade, Ilze
Liepinsh, Edgars
Strele, Ieva
Makrecka, Marina
Bierhaus, Angelika
Lejnieks, Aivars
Pirags, Valdis
Dambrova, Maija
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Aims: The present study was undertaken to investigate the relationship between glyoxalase 1 (Glo1) enzyme
activity and painful diabetic neuropathy (DN) in patients with diabetes mellitus.
Methods: Glo1 activity and biochemical markers were determined in blood samples from 108 patients with
type 1 diabetes, 109 patients with type 2 diabetes, and 132 individuals without diabetes as a control. Painful
and painless peripheral DN was assessed and multivariate regression analysis was used to determine
independent association of Glo1 activity with occurrence of painful DN.
Results: In patients with type 1 and type 2 diabetes mellitus and painful DN compared to patients with
painless DN, Glo1 activity was significantly reduced by 12 and 14%, respectively. The increase in Glo1 activity
was significantly associated with reduced occurrence of painful DN after adjusting for confounders by
multivariate analysis.
Conclusions: Our results demonstrate for the first time that Glo1 activity is lower in patients with both types of
diabetes mellitus who were diagnosed with painful DN. These data support the hypothesis that Glo1 activity
modulates the phenotype of DN and warrant further investigation into the role of Glo1 in DN.
© 2013 Elsevier Inc. All rights reserved.
Description
Keywords
Research Subject Categories::MEDICINE , Glyoxalase 1 , Diabetes mellitus , Painful diabetic neuropathy , Type 1 diabetes , Type 2 diabetes