A common promoter variant of the gene encoding cyclooxygenase-1 (PTGS1) is related to decreased incidence ofmyocardial infarction in patients with coronary artery disease
dc.contributor.author | Latkovskis, Gustavs | |
dc.contributor.author | Licis, Normunds | |
dc.contributor.author | Krivmane, Baiba | |
dc.contributor.author | Erglis, Andrejs | |
dc.date.accessioned | 2015-12-02T20:08:06Z | |
dc.date.available | 2015-12-02T20:08:06Z | |
dc.date.issued | 2011 | |
dc.description.abstract | Cyclooxigenase (COX)-1, formally known as prostanglandin endoperoxideH synthetase-1,mediates synthesis of prostaglandin H2,which is subsequently converted to various biologically active metabolites including thromboxane (TX) A2 [1]. TXA2 is synthesized and released by activated platelets and strongly reinforces thrombus formation, a critical pathway in the pathogenesis of myocardial infarction (MI). Inhibition of COX-1-derived TXA2 in platelets by low-dose aspirin administration reduces incidence of MI [2]. Hypothetically, MI-risk could also be modified by genetic variants that affect activity or expression of COX-1. Many single nucleotide polymorphisms (SNP) in the gene encoding COX-1 (PTGS1) have been described; including functional alterations in both coding and non-coding regions [3,4].We have evaluated if two of such variations are related to the risk ofMI in a historic cohort of patients with coronary artery disease (CAD). | en_US |
dc.identifier.doi | 10.1016/j.thromres.2010.12.019 | |
dc.identifier.uri | https://dspace.lu.lv/dspace/handle/7/31265 | |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.ispartofseries | Thrombosis Research;Vol. 125, No. 6 | |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_US |
dc.subject | Research Subject Categories::MEDICINE | en_US |
dc.title | A common promoter variant of the gene encoding cyclooxygenase-1 (PTGS1) is related to decreased incidence ofmyocardial infarction in patients with coronary artery disease | en_US |
dc.title.alternative | Letter to the Editors-in-Chief | |
dc.type | info:eu-repo/semantics/other | en_US |