Gallija-68 [68Ga] un fluora-18 [18F] izotopu iegūšana un izmantošana radiofarmaceitisko preparātu sintēzē
Date
2017
Authors
Mamis, Edgars
Journal Title
Journal ISSN
Volume Title
Publisher
Latvijas Universitāte
Abstract
Gallija-68 [68Ga] un fluora-18 [18F] izotopu iegūšana un izmantošana radiofarmaceitisko preparātu sintēzē. Mamis E., zinātniskais vadītājs Prof. Dr.h.c. Chem Andris Actiņš, zinātniskie konsultanti Mg. Chem Jāzeps Malnačs un Mg. Med. Phys., Dipl. Ing., Mg. Sc. Ing Linda Meistere. Maģistra darbs, 54 lappuses, 28 attēli, 12 tabulas, 20 literatūras avoti. Latviešu valodā. Darbā ir apkopota literatūra par radionuklīdu iegūšanas procesiem kodolreakcijas ceļā, izmantojot daļiņu paātrinātāju – ciklotronu un 68Ge/68Ga ģeneratoru, sintēzes procesiem noteiktu radiofarmaceitisko preparātu iegūšanā, kā arī pozitronu emisijas tomogrāfijas tehnoloģiju un tās izmantošanas iespējas onkoloģisko saslimšanu diagnostikā. Izstrādāts detalizēts apraksts par diviem radiofarmaceitiskajiem preparātiem – [18F]-Fluorometilholīns un [68Ga]-Prostatas membrānas specifiskais antigēns-11. Maģistra darba izstrādes ietvaros tika veiktas praktiskās darbības, eksperimenti, kuru laikā tika iegūti [18F] un [68Ga] radionuklīdi, kurus tālāk izmantoja radiofarmaceitisko preparātu ražošanās un prostatas vēža diagnostikai. Saražotajiem radiofarmaceitiskajiem preparātiem tika veiktas kvalitātes kontroles analīzes, lai identificētu konkrētos radionuklīdus, radiofarmaceitiskos preparātus un noteiktu to tīrības pakāpi.
Production of Gallium-68 [68Ga] and [18F] isotopes and their further use in radiopharmaceutical synthesis. Mamis E., scientific supervisor Prof. Dr.h.c. Chem Andris Actiņš, scientific consultants Mg. Chem Jāzeps Malnačs and Mg. Med. Phys., Dipl. Ing., Mg. Sc. Ing Linda Meistere. Master’s thesis 54 pages, 28 figures, 12 tables, 20 references. In Latvian. In this work literature about PET technology and production of radionuclides by nuclear reactions using cyclotron and 68Ge/68Ga generator, synthesis of radiopharmaceuticals and use of PET in cancer diagnostics were summarized. One [68Ga] and one [18F] radiopharmaceuticals are described - [18F]-Fluoromethylcholine and [68Ga]-Prostate membrane specific antigen - 11. In this work [68Ga] and [18F] radionuclides were produced, which then were used in radiopharmaceutical synthesis and prostate cancer diagnostics. Quality control analysis of manufactured radiopharmaceuticals were performed.
Production of Gallium-68 [68Ga] and [18F] isotopes and their further use in radiopharmaceutical synthesis. Mamis E., scientific supervisor Prof. Dr.h.c. Chem Andris Actiņš, scientific consultants Mg. Chem Jāzeps Malnačs and Mg. Med. Phys., Dipl. Ing., Mg. Sc. Ing Linda Meistere. Master’s thesis 54 pages, 28 figures, 12 tables, 20 references. In Latvian. In this work literature about PET technology and production of radionuclides by nuclear reactions using cyclotron and 68Ge/68Ga generator, synthesis of radiopharmaceuticals and use of PET in cancer diagnostics were summarized. One [68Ga] and one [18F] radiopharmaceuticals are described - [18F]-Fluoromethylcholine and [68Ga]-Prostate membrane specific antigen - 11. In this work [68Ga] and [18F] radionuclides were produced, which then were used in radiopharmaceutical synthesis and prostate cancer diagnostics. Quality control analysis of manufactured radiopharmaceuticals were performed.
Description
Keywords
Ķīmija , CIKLOTRONS , 68Ge/68Ga ĢENERATORS , [18F] RADIONUKLĪDS , [68Ga] RADIONUKLĪDS , POZITRONU EMISIJAS TOMOGRĀFIJA