Latvijas rūpniecībai aktuālu farmaceitiski aktīvo vielu kristālsolvāti
Date
2013
Authors
Veldre, Kaspars
Journal Title
Journal ISSN
Volume Title
Publisher
Latvijas Universitāte
Abstract
Promocijas darbs veltīts Latvijas tautsaimniecībai aktuālu farmaceitiski aktīvo vielu (FAV)
izpētei. Veikti apskatīto vielu kristālsolvātu meklējumi un iegūtas līdz šim neaprakstītas vielu
kristāliskās formas. Novērtēta iegūto formu stabilitāte iegūšanas, ražošanas un uzglabāšanas
apstākļos. Atsevišķām FAV veikta struktūras noteikšana, gan izmantojot pulvera rentgendifraktometriju,
gan monokristālu rentgendifraktometriju.
Iegūtie rezultāti ir aktuāli zāļu ražotājiem, kā arī tiem ir zinātniska nozīme no FAV īpašību
apzināšanas un metožu attīstības viedokļa.
.
This doctoral thesis project is focused on investigation of active pharmaceutical ingredients (API), which are important for industry of Latvia. Crystal solvate search and screening was performed for compounds described and novel crystalline forms were obtained. Stability in acquisition, production and storage conditions was evaluated. Crystal structure determination was performed for selected API, using powder x-ray diffractometry and single crystal diffractometry. Results obtained are useful for pharmaceutical companies, as well as they have scientific significance by increasing knowledge on API properties and developing methods of analysis.
This doctoral thesis project is focused on investigation of active pharmaceutical ingredients (API), which are important for industry of Latvia. Crystal solvate search and screening was performed for compounds described and novel crystalline forms were obtained. Stability in acquisition, production and storage conditions was evaluated. Crystal structure determination was performed for selected API, using powder x-ray diffractometry and single crystal diffractometry. Results obtained are useful for pharmaceutical companies, as well as they have scientific significance by increasing knowledge on API properties and developing methods of analysis.
Description
Keywords
Ķīmija , kristālsolvāti , vielas stāvokļa diagramma , nestehiometriskie solvāti , vielu termodinamiskā stabilitāte , fāžu pāreju kinētika , Chemistry , crystal solvates , phase diagram , nonstoichiometric solvates , thermodynamical stability , phase transition kinetics