Novel 1D photonic metal oxide nanostructures for early stage cancer detection (CanBioSe)

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https://dspace-dev.lu.lv/handle/7/50033

Vienošanās Nr./ Grant agreement ID: 778157

Finansē saskaņā ar / Funded under: H2020-EU.1.3.3.

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Browsing Novel 1D photonic metal oxide nanostructures for early stage cancer detection (CanBioSe) by Author "Iatsunskyi, Igor"

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    Optical properties of ZnO deposited by atomic layer deposition (ALD) on Si nanowires
    (2018-10-01) Graniel, Octavio; Fedorenko, Viktoriia; Viter, Roman; Iatsunskyi, Igor; Nowaczyk, Grzegorz; Weber, Matthieu; Załęski, Karol; Jurga, Stefan; Smyntyna, Valentyn; Miele, Philippe; Ramanavicius, Arunas; Balme, Sebastien; Bechelany, Mikhael
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    Photoluminescence immunosensor based on bovine leukemia virus proteins immobilized on the ZnO nanorods
    (2019-04-15) Viter, Roman; Savchuk, Maryna; Starodub, Nickolay; Balevicius, Zigmas; Tumenas, Saulius; Ramanaviciene, Almira; Jevdokimovs, Daniels; Erts, Donats; Iatsunskyi, Igor; Ramanavicius, Arunas
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    Photoluminescent Detection of Human T-Lymphoblastic Cells by ZnO Nanorods
    (MDPI: Molecules, 2020-07-10) Tamashevski, Alexander; Harmaza, Yuliya; Slobozhanina, Ekaterina; Viter, Roman; Iatsunskyi, Igor
    The precise detection of cancer cells currently remains a global challenge. One-dimensional (1D) semiconductor nanostructures (e.g., ZnO nanorods) have attracted attention due to their potential use in cancer biosensors. In the current study, it was demonstrated that the possibility of a photoluminescent detection of human leukemic T-cells by using a zinc oxide nanorods (ZnO NRs) platform. Monoclonal antibodies (MABs) anti-CD5 against a cluster of differentiation (CD) proteins on the pathologic cell surface have been used as a bioselective layer on the ZnO surface. The optimal concentration of the protein anti-CD5 to form an effective bioselective layer on the ZnO NRs surface was selected. The novel biosensing platforms based on glass/ZnO NRs/anti-CD5 were tested towards the human T-lymphoblast cell line MOLT-4 derived from patients with acute lymphoblastic leukemia. The control tests towards MOLT-4 cells were performed by using the glass/ZnO NRs/anti-IgG2a system as a negative control. It was shown that the photoluminescence signal of the glass/ZnO NRs/anti-CD5 system increased after adsorption of T-lymphoblast MOLT-4 cells on the biosensor surface. The increase in the ZnO NRs photoluminescence intensity correlated with the number of CD5-positive MOLT-4 cells in the investigated population (controlled by using flow cytometry). Perspectives of the developed ZnO platforms as an efficient cancer cell biosensor were discussed.