Klīnisko rezultātu novērojums pēc perkutānās transluminālās koronārās angioplastijas ar zālēm pildītiem stentiem.
Date
2007
Authors
Vvedenska, Gaļina
Journal Title
Journal ISSN
Volume Title
Publisher
Latvijas Universitāte
Abstract
2. KOPSAVILKUMS
Darba pamatojums: saslimstība un mirstība no kardiovaskulārām (KV) slimībām ir ļoti nozīmīga medicīniska un sociālekonomiska problēma visā pasaulē, jo vismaz 50% no kopējās mirstības ir KV slimību dēļ. Miokarda revaskularizācija ir viena no svarīgākajām koronāras sirds slimības (KSS) ārstēšanas metodēm. Arvien lielāku vietu KSS ārstēšanā ieņem perkutānā koronārā translumināla angioplastija (PTCA), izmantojot ar zālēm pildītus stentus (DES), bet pastāv bažas par iespējamu stentu trombožu pieaugumu.
Darba mērķi: Noskaidrot klīnisko notikumu biežumu pacientiem pēc PTCA ar DES. Lai sasniegtu darba mērķi, bija nepieciešams noskaidrot pēc DES implantācijas slimnieku skaitu ar fatālu un nefatālu infarktu, sāpem krūtīs, atkārtotu miokarda revaskularizāciju pēc PTCA.
Materiāli un metodes: Darba ietvaros tika veikta retrospektīva analīze par pacientiem (n=197), kam Paula Stradiņa Klīniskās universitātes slimnīcas Latvijas Kardioloģijas centrā tika veikta PTCA ar DES. Tika veikta telefoniska anketēšana pacientiem, kam PTCA tika veikta laika posmā no 2005. gada 6. jūlija līdz 2006. gada 24. maijam. Atsevišķi analizēti pirmie seši un divpadsmit mēneši pēc veiktās PTCA.
Rezultāti: Pirmajā pusgadā pēc veiktas PTCA ar DES tika diagnosticēts nefatāls MI n=2 (1%), sāpes krūtīs n= 41(20,8%) gadījumu un otrajā pusgadā- nefatāls MI 0%, sāpes krūtīs n=6(18,2%). Atkārtota PTCA tika veikta n=10(5%) pirmajā pusgadā un n=2(6,1%) otrajā pusgadā. Pirmajā pusgadā klopidogrelu lietoja n=191(97%) pacientu, bet otrajā pusgadā n=13( 39%).
Secinājumi. Notikumu skaits pirmajā pusgadā pēc DES implantācijas ir zems. Tomēr nepieciešami ilgstošāki novērojumi, lai noskaidrotu klīnisku notikumu skaitu garākā laika posmā.
3. SUMMARY The title of Diploma Work is “Clinical follow-up after percutaneous transluminal coronary angioplasty with drug eluting stents”, the work was performed by Gaļina Buzajeva, student of Medicine Faculty University of Latvia and supervised by Gustavs Latkovskis, MD, PhD. Introduction: Morbidity and death rates from cardiovascular diseases is a very important medical and social economic problem worldwide, because at least 50% of total deaths are due to cardiovascular diseases. Revascularisation of myocardium is one of the most important treatment methods for coronary heart disease. Increasingly large proportion of patients are treated with percutaneous transluminal coronary angioplasty (PTCA) using drug-eluting stents (DES), but there is some concern about possible increase of stent thrombosis. Aim: To ascertain the frequency of clinical events for patients after PCTA with DES. To reach the main goal it was necessary to find out the number of patients after DES implantation with fatal and nonfatal infarction, chest pain, and recurrent revascularisation after index PTCA. Materials and methods: A retrospective analysis of patients (n=197) after PCTA with DES performed at the Latvian Centre of Cardiology, Paula Stradiņa Clinical University hospital was done. Telephonic questionnairing was done about the period of time from 6th of July 2005 till 24th of May 2006. The periods of the first six (n=197) and the second six months (n=33) after the PTCA were separately analysed. Results: Nonfatal myocardial infarction and chest pain was observed in n=2(1.0%) and n=41(20.8%) cases, respectively, in the first half-year after PCTA with DES, nonfatal myocardial infarction and chest pain in n=0(0%) and n=6(18,2%) cases in the second half-year were diagnosed. Repeated of PTCA was done in n=10(5%) in first half a year and in n=2(6,1%) in second half a year. In the first half a year clopidogrelum used n=191(97%) patients, but in the second half a year used only n=13( 39%) patients. Conclusions: The frequency of events after DES implantation is low. However longer follow-up observations are needed to determine long-term results, especially regarding the influence of discontinuation of clopidogrel on events.
3. SUMMARY The title of Diploma Work is “Clinical follow-up after percutaneous transluminal coronary angioplasty with drug eluting stents”, the work was performed by Gaļina Buzajeva, student of Medicine Faculty University of Latvia and supervised by Gustavs Latkovskis, MD, PhD. Introduction: Morbidity and death rates from cardiovascular diseases is a very important medical and social economic problem worldwide, because at least 50% of total deaths are due to cardiovascular diseases. Revascularisation of myocardium is one of the most important treatment methods for coronary heart disease. Increasingly large proportion of patients are treated with percutaneous transluminal coronary angioplasty (PTCA) using drug-eluting stents (DES), but there is some concern about possible increase of stent thrombosis. Aim: To ascertain the frequency of clinical events for patients after PCTA with DES. To reach the main goal it was necessary to find out the number of patients after DES implantation with fatal and nonfatal infarction, chest pain, and recurrent revascularisation after index PTCA. Materials and methods: A retrospective analysis of patients (n=197) after PCTA with DES performed at the Latvian Centre of Cardiology, Paula Stradiņa Clinical University hospital was done. Telephonic questionnairing was done about the period of time from 6th of July 2005 till 24th of May 2006. The periods of the first six (n=197) and the second six months (n=33) after the PTCA were separately analysed. Results: Nonfatal myocardial infarction and chest pain was observed in n=2(1.0%) and n=41(20.8%) cases, respectively, in the first half-year after PCTA with DES, nonfatal myocardial infarction and chest pain in n=0(0%) and n=6(18,2%) cases in the second half-year were diagnosed. Repeated of PTCA was done in n=10(5%) in first half a year and in n=2(6,1%) in second half a year. In the first half a year clopidogrelum used n=191(97%) patients, but in the second half a year used only n=13( 39%) patients. Conclusions: The frequency of events after DES implantation is low. However longer follow-up observations are needed to determine long-term results, especially regarding the influence of discontinuation of clopidogrel on events.
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Medicīna