Identification of biomarkers for diagnosis of thyroid cancer and exploration of their functional role in cancer development
Date
2015
Authors
Ābols, Artūrs
Journal Title
Journal ISSN
Volume Title
Publisher
Latvijas Universitāte
Abstract
Šī doktora darba ietvaros tika identificēts multipleks biomerķieru modelis
vairogdziedzera vēža pacientiem, kam nepieciešams apstiprinājums FNAB. Kā arī šajā darbā
autors pēta TFF3, vienu no daudzsološākiem vairogdziedzera vēža biomarķieriem, funkcijas
vairogdziedzera vēzī un demonstrē, ka tas var funkcionēt gan kā tumor suppresors, gan onkogēns
atkarībā no šūnu konteksta. Šī darba ietvaros tika arī sistemātiski pētīts vēža asociēto
autoantivielu repertuārs vairogdziedzera vēža pacientos. Kopumā šis darbs sniedz dziļāku
izpratni par molekulārām izmaiņām, kas noved pie vairogdziedzera vēža attīstības un identificē
potenciālos biomarķierus diagnostikas testa attīstīšanai un signālceļus terapijas attīstīšanai
vairogdziedzera vēža pacientos.
In this doctoral thesis, a multiplex biomarker model for thyroid cancer was identified and warrants further studies in FNAB to improve it. Also in this work, for the first time author investigated the functional role of TFF3 - one of the most promising thyroid cancer tissue biomarker known so far, and demonstrated that TFF3 can act as tumor suppresor or onco gene depending on cellular context. Furthermore, in this work for the first time author systematically studied the repertoire of cancer-associated autoantibodies in patients with thyroid cancer. Hence, this study provided a deeper insight into the molecular alterations leading to the development of thyroid cancer and revealed biomarkers for the diagnosis and putative therapeutic targets for the development of drugs against thyroid cancer.
In this doctoral thesis, a multiplex biomarker model for thyroid cancer was identified and warrants further studies in FNAB to improve it. Also in this work, for the first time author investigated the functional role of TFF3 - one of the most promising thyroid cancer tissue biomarker known so far, and demonstrated that TFF3 can act as tumor suppresor or onco gene depending on cellular context. Furthermore, in this work for the first time author systematically studied the repertoire of cancer-associated autoantibodies in patients with thyroid cancer. Hence, this study provided a deeper insight into the molecular alterations leading to the development of thyroid cancer and revealed biomarkers for the diagnosis and putative therapeutic targets for the development of drugs against thyroid cancer.
Description
Elektroniskā versija nesatur pielikumus
Keywords
Dzīvās dabas zinātnes , Vairogdziedzeris , Vēzis (diagnostika) , Thyroid gland , Cancer (diagnosis)