Identification of biomarkers for diagnosis of thyroid cancer and exploration of their functional role in cancer development
| dc.contributor.advisor | Linē, Aija | en_US |
| dc.contributor.author | Ābols, Artūrs | en_US |
| dc.contributor.other | Latvijas Universitāte. Bioloģijas fakultāte | en_US |
| dc.date.accessioned | 2015-06-21T01:01:15Z | |
| dc.date.available | 2015-06-21T01:01:15Z | |
| dc.date.issued | 2015 | en_US |
| dc.description | Elektroniskā versija nesatur pielikumus | en_US |
| dc.description.abstract | Šī doktora darba ietvaros tika identificēts multipleks biomerķieru modelis vairogdziedzera vēža pacientiem, kam nepieciešams apstiprinājums FNAB. Kā arī šajā darbā autors pēta TFF3, vienu no daudzsološākiem vairogdziedzera vēža biomarķieriem, funkcijas vairogdziedzera vēzī un demonstrē, ka tas var funkcionēt gan kā tumor suppresors, gan onkogēns atkarībā no šūnu konteksta. Šī darba ietvaros tika arī sistemātiski pētīts vēža asociēto autoantivielu repertuārs vairogdziedzera vēža pacientos. Kopumā šis darbs sniedz dziļāku izpratni par molekulārām izmaiņām, kas noved pie vairogdziedzera vēža attīstības un identificē potenciālos biomarķierus diagnostikas testa attīstīšanai un signālceļus terapijas attīstīšanai vairogdziedzera vēža pacientos. | en_US |
| dc.description.abstract | In this doctoral thesis, a multiplex biomarker model for thyroid cancer was identified and warrants further studies in FNAB to improve it. Also in this work, for the first time author investigated the functional role of TFF3 - one of the most promising thyroid cancer tissue biomarker known so far, and demonstrated that TFF3 can act as tumor suppresor or onco gene depending on cellular context. Furthermore, in this work for the first time author systematically studied the repertoire of cancer-associated autoantibodies in patients with thyroid cancer. Hence, this study provided a deeper insight into the molecular alterations leading to the development of thyroid cancer and revealed biomarkers for the diagnosis and putative therapeutic targets for the development of drugs against thyroid cancer. | en_US |
| dc.identifier.other | 50701 | en_US |
| dc.identifier.uri | https://dspace.lu.lv/dspace/handle/7/28378 | |
| dc.language.iso | eng | en_US |
| dc.publisher | Latvijas Universitāte | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Dzīvās dabas zinātnes | en_US |
| dc.subject | Vairogdziedzeris | |
| dc.subject | Vēzis (diagnostika) | |
| dc.subject | Thyroid gland | |
| dc.subject | Cancer (diagnosis) | |
| dc.title | Identification of biomarkers for diagnosis of thyroid cancer and exploration of their functional role in cancer development | en_US |
| dc.title.alternative | Vairogdziedzera audzēju veidošanās molekulāro mehānismu izpēte un biomarķieru identificēšana | en_US |
| dc.type | info:eu-repo/semantics/doctoralThesis | en_US |