Ar amīniem modificētu 1,4-dihidropiridīna atvasinājumu sintēze un īpašību pētījumi
Date
2016
Authors
Jēkabsone, Madara
Journal Title
Journal ISSN
Volume Title
Publisher
Latvijas Universitāte
Abstract
Sintezēts nekomerciāli pieejamais didodecil 2,6-bis(brometil)-4-fenil-1,4-dihidropiridīna-3,5-dikarboksilāts. Tam veikta broma aizvietošana 2,6-vietās ar dažādiem amīniem, iegūstot desmit jaunus oriģinālus savienojumus. Dots jaunsintezēto savienojumu fiziko-ķīmisko īpašību raksturojums, noteikta sintezēto savienojumu reducējošās kapacitātes aktivitāte, izmantojot fosformolibdēna kompleksa metodi, veikta antiradikālās aktivitātes noteikšana ar 1,1-difenil-2-pikrilhidrazil brīvo radikāļu metodi. Noskaidrots, ka no visiem jaunsintezētajiem savienojumiem, visaktīvākais ir didodecil 2,6-bis[(5-fluoro-2,6-diokso-3-tetrahidrofurān-2-il-pirimidīn-1-il)metil]-4-fenil-1,4-dihidropiridīna-3,5-dikarboksilāts, kas uzrāda augstu antiradikālo aktivitāti (55%) un reducējošo kapacitāti (26%).
Non-commercial didodecyl 2,6-bis (bromomethyl) -4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate was synthesized. Substitution of bromine with a variety of amines at 2,6-positions of 1,4-DHP cycle, resulting in ten new original compounds was carried out. Physico-chemical properties of synthesized compounds were characterized. Reductive capacity of synthesized compounds was tested using phosphomolybdenum complex method, antiradical activity of compounds was evaluated using the 1,1-diphenyl-2-picrylhydrazyl free radical method. It is established didodecyl 2,6-bis[(5-fluoro-2,6-dioxo-3-tetrahydrofuran-2-il-pyrimidin-1-il)methyl]-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate is the most active. It possesses high antiradical activity (55%) and reducing capacity (26%) among all newly synthesized compounds.
Non-commercial didodecyl 2,6-bis (bromomethyl) -4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate was synthesized. Substitution of bromine with a variety of amines at 2,6-positions of 1,4-DHP cycle, resulting in ten new original compounds was carried out. Physico-chemical properties of synthesized compounds were characterized. Reductive capacity of synthesized compounds was tested using phosphomolybdenum complex method, antiradical activity of compounds was evaluated using the 1,1-diphenyl-2-picrylhydrazyl free radical method. It is established didodecyl 2,6-bis[(5-fluoro-2,6-dioxo-3-tetrahydrofuran-2-il-pyrimidin-1-il)methyl]-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate is the most active. It possesses high antiradical activity (55%) and reducing capacity (26%) among all newly synthesized compounds.
Description
Keywords
Farmācija , 1,4-DIHIDROPIRIDĪNI , AMĪNI , REDUCĒJOŠĀ KAPACITĀTE , ANTIRADIKĀLĀ AKTIVITĀTE