2,6-Diazabiciklo[2.2.2]oktān-3,5-dionu sintēze
Date
2012
Authors
Pelšs, Jānis
Journal Title
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Publisher
Latvijas Universitāte
Abstract
2,6-Diazabiciklo[2.2.2]oktān-3,5-dionu sintēze. Pelšs J., zinātniskie vadītāji Dr. chem., vadošais pētnieks Žalubovskis R., Grandāne A., Dr. habil. chem. prof. Zicmanis A. Bakalaura darbs, 46 lappuses, 3 attēli, 18 tabulas, 28 literatūras avoti. Latviešu valodā.
Darbā ir veikta 2,6-diazabiciklo[2.2.2]oktān-3,5-dionu sintēze trīskomponentu viena reaktora reakcijā. Tika sintezēta virkne 2,6-diazabiciklo[2.2.2]oktān-3,5-dionu ar dažādiem alkil- un arilaizvietotājiem pie bicikla C-1 un C-8 atomiem. Iegūto savienojumu struktūra tika pierādīta ar KMR spektroskopiju. 2,6-Diazabiciklo[2.2.2]oktān-3,5-diona reģioizomēra bicikliskā struktūra tika apstiprināta ar rentgenstruktūranalīzi. 2,6-DIAZABICIKLO[2.2.2]OKTĀN-3,5-DIONS, TRĪSKOMPONENTU REAKCIJA, AMĪDU IEKŠMOLEKULĀRĀ CIKLIZĀCIJA.
Synthesis of 2,6-diazabicyclo[2.2.2]octane-3,5-diones. Pelšs J., scientific supervisors Dr. chem., principal scientist Žalubovskis R., Grandāne A., Dr. habil. chem. prof. Zicmanis A. Bachelor’s thesis, 46 pages, 3 figures, 18 tables, 28 literature references. In this work, 2,6-diazabicyclo[2.2.2]octane-3,5-diones were synthesized by a way of a three-component one-pot reaction. A series of 2,6-diazabicyclo[2.2.2]octane-3,5-diones with a variety of subtituents at the C-1 and C-8 atoms of the bicyclic structure. The structure of the synthesized compunds was confirmed by NMR spectra. The bicyclic structure of the regioisomer of 2,6-diazabicyclo[2.2.2]octane-3,5-dione was also confimed by X-ray structure analysis. 2,6-DIAZABICYCLO[2.2.2]OCTANE-3,5-DIONE, THREE-COMPONENT REACTION, INTRA-MOLECULAR CYCLIZATION OF AMIDES.
Synthesis of 2,6-diazabicyclo[2.2.2]octane-3,5-diones. Pelšs J., scientific supervisors Dr. chem., principal scientist Žalubovskis R., Grandāne A., Dr. habil. chem. prof. Zicmanis A. Bachelor’s thesis, 46 pages, 3 figures, 18 tables, 28 literature references. In this work, 2,6-diazabicyclo[2.2.2]octane-3,5-diones were synthesized by a way of a three-component one-pot reaction. A series of 2,6-diazabicyclo[2.2.2]octane-3,5-diones with a variety of subtituents at the C-1 and C-8 atoms of the bicyclic structure. The structure of the synthesized compunds was confirmed by NMR spectra. The bicyclic structure of the regioisomer of 2,6-diazabicyclo[2.2.2]octane-3,5-dione was also confimed by X-ray structure analysis. 2,6-DIAZABICYCLO[2.2.2]OCTANE-3,5-DIONE, THREE-COMPONENT REACTION, INTRA-MOLECULAR CYCLIZATION OF AMIDES.
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