Hipfizāro un dzimumhormonu izmaiņu ietekme uz epilepsijas norisi sievietēm.
Date
2007
Authors
Āva, Lauma
Journal Title
Journal ISSN
Volume Title
Publisher
Latvijas Universitāte
Abstract
Darba mērķis bija noskaidrot hipofīzes un steroīdo hormonu izmaiņu ietekmi uz epilepsijas kritērijiem sievietēm ar idiopātisku epilepsiju fertilā vecumā. Tika izmantoti dati par 71 sievieti ar idiopātisku epilepsiju vecumā no 13 – 55 gadiem. Kā kontrolgrupa tika izmantoti hormonālo analīžu un elektroencefalogrāfijas rādītāju rezultāti 14 sievietēm vecumā no 18 līdz 50 gadiem. Hormonu analīzēm tika ņemtas asinis, ņemot vērā tekošo menstruālā cikla fāzi. Tika noteikts folikulus stimulējošā hormona, luteinizējošā hormona, prolaktīna, estradiola, progestetrona, dihidroepiandrostendiona sulfāta un testosterona līmenis. Darba rezultātos konstatēts, ka 73% gadījumu sievietēm ar epilepsiju fertilā vecumā ir hormonālas izmaiņas, pie tam pastāv savstarpēja korelācija starp hormonu līmeņu izmaiņām.Hipofizāro un dzimumhormonu līmeņi asinīs korelē ar elektroencefalogrāfijas rādītājiem, un izmainīti šo hormonu līmeņi un estradiola/progesterona koeficients >100 luteīnajā fāzē ierosina epileptiformus paroksizmus, bet folikulārajā fāzē paaugstināts prolaktīna līmenis izraisa epilepsijas pacientiem tipiskās izmaiņas elektroencefalogrammā. Izmainīti hormonu līmeņi un estradiola/progesterona koeficients >100 pacientēm ar epilepsiju, korelē ar lēkmju biežumu gadā.
The aim of the investigation was to determine the changes of sex steroid and pituary hormonal disbalance that influence epileptic criterions on women in fertile age, who are epileptic patients. Data about 71 women with epilepsy (at age 13 – 55) and 14 controls (at age 18 – 55) in the investigation were used. All patients and the controls underwent the following blood hormone level tests: follicle stimulating hormone, luteinizing hormone, estradiol, progesterone, androstendione, prolactine and testosterone. The results of this investigation revealed, that hormonal disbalanse was identified to 73% females with epilepsy. There is a difference between nature of changes of electroencephalographic showings for patients with changed and not changed hormone levels and coefficient of estradiol/progesterone<100 and>100 in luteal phase and changed and not changed level of prolactine in follicular phase of menstrual cycle. Correlation between pituary hormones and sex steroids ad frequency of seizures were constituted.
The aim of the investigation was to determine the changes of sex steroid and pituary hormonal disbalance that influence epileptic criterions on women in fertile age, who are epileptic patients. Data about 71 women with epilepsy (at age 13 – 55) and 14 controls (at age 18 – 55) in the investigation were used. All patients and the controls underwent the following blood hormone level tests: follicle stimulating hormone, luteinizing hormone, estradiol, progesterone, androstendione, prolactine and testosterone. The results of this investigation revealed, that hormonal disbalanse was identified to 73% females with epilepsy. There is a difference between nature of changes of electroencephalographic showings for patients with changed and not changed hormone levels and coefficient of estradiol/progesterone<100 and>100 in luteal phase and changed and not changed level of prolactine in follicular phase of menstrual cycle. Correlation between pituary hormones and sex steroids ad frequency of seizures were constituted.
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Medicīna