Fibronectin-binding nanoparticles for intracellular targeting addressed by B. burgdorferi BBK32 protein fragments

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dc.contributor.authorRanka, Renate
dc.contributor.authorPetrovskis, Ivars
dc.contributor.authorSominskaya, Irina
dc.contributor.authorBogans, Janis
dc.contributor.authorBruvere, Ruta
dc.contributor.authorAkopjana, Inara
dc.contributor.authorOse, Velta
dc.contributor.authorTimofejeva, Irena
dc.contributor.authorBrangulis, Kalvis
dc.contributor.authorPumpens, Pauls
dc.contributor.authorBaumanis, Viesturs
dc.date.accessioned2015-12-02T09:46:45Z
dc.date.available2015-12-02T09:46:45Z
dc.date.issued2013-01
dc.description.abstractVirus-like particles (VLPs) are created by the self-assembly of multiple copies of envelope and/or capsid proteins from many viruses, mimicking the conformation of a native virus. Such noninfectious nanostructures are mainly used as antigen-presenting platforms, especially in vaccine research; however, some of them recently were used as scaffolds in biotechnology to produce targeted nanoparticles for intracellular delivery. This study demonstrates the creation of fusion VLPs using hepatitis B core protein-based system maintaining a fibronectin-binding property from B. burgdorferi BBK32 protein, including the evidence of particles’ transmission to BHK-21 target cells via caveolae/rafts endocythosis. These results make this construct to be an attractive model in development of HBc-based nanoparticles for cellular targeting applications and highlights the fragment of B. burgdorferi BBK32 as a novel cellular uptake-promoting peptide.en_US
dc.description.sponsorshipThis work was supported by grant of Latvian Council of Science, Nr. 10.0029.3 and by ESF Projecten_US
dc.identifier.doi10.1016/j.nano.2012.05.003
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S1549963412001839
dc.identifier.urihttps://dspace.lu.lv/dspace/handle/7/31258
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation1DP/1.1.2.0/09/APIA/VIAA/150en_US
dc.relation.ispartofseriesBasik science;Vol. 9
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Biologyen_US
dc.titleFibronectin-binding nanoparticles for intracellular targeting addressed by B. burgdorferi BBK32 protein fragmentsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
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Bioloģija, vides un rūpnieciskā biotehnoloģijas/Biological sciences, Environmental and Industrial biotechnology