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- ItemCan changes in starch content and peroxidase activity be used as rooting phase markers for rhododendron leaf bud cuttings?(Polish Academy of Sciences Publishing House, 2011) Megre, Dace; Dokane, Kristine; Kondratovics, Uldis
- ItemComparison of telomere length between population-specificmitochondrial haplogroups among different age groupsin a Latvian population(Elsevier, 2015) Elferts, Didzis; Zole, Egija; Ķimsis, Jānis; Krūmiņa, Astrīda; Narels, Kristaps; Pole, Ilva; Ranka, Renāte; Pliss, Liana
- ItemCrystal structures of the Erp protein family members ErpP and ErpC from Borrelia burgdorferi reveal the reason for different affinities for complement regulator factor H(Elsevier, 2015) Brangulis, Kalvis; Petrovskis, Ivars; Kazaks, Andris; Akopjana, Inara; Tars, KasparsBorrelia burgdorferi is the causative agent of Lyme disease, which can be acquired after the bite of an infected Ixodes tick. As a strategy to resist the innate immunity and to successfully spread and proliferate, B. burgdorferi expresses a set of outermembrane proteins that are capable of binding complement regulator factorH(CFH), factor H-like protein 1 (CFHL-1) and factor H-related proteins (CFHR) to avoid complement-mediated killing. B. burgdorferi B31 contains three proteins that belong to the Erp (OspE/F-related) protein family and are capable of binding CFH and some CFHRs, namely ErpA, ErpC and ErpP. We have determined the crystal structure of ErpP at 2.53 Å resolution and the crystal structure of ErpC at 2.15 Å resolution. Recently, the crystal structure of the Erp familymember OspE fromB. burgdorferi N40was determined in complexwith CFH domains 19–20, revealing the residues involved in the complex formation. Despite the high sequence conservation between ErpA, ErpC, ErpP and the homologous protein OspE (78–80%), the affinity for CFH and CFHRs differsmarkedly among the Erp family members, suggesting that ErpC may bind only CFHRs but not CFH. A comparison of the binding site in OspE with those of ErpC and ErpP revealed that the extended loop region,which is only observed in the potential binding site of ErpC, plays an important role by preventing the binding of CFH. These results can explain the inability of ErpC to bind CFH, whereas ErpP and ErpA still possess the ability to bind CFH.
- ItemDNA-binding studies of AV-153, an antimutagenic and DNA repair-stimulating derivative of 1,4-dihydropiridine(Elsevier, 2014) Buraka, E.; Yu-Chian Chen, C.; Gavare, M.; Grube, M.; Makarenkova, G.; Nikolajeva, V.; Bisenieks, I.; Brūvere, I.; Bisenieks, E.; Duburs, G.; Sjakste, N.
- ItemDoes shoot anatomical heterogeneity influence Ex Vitro adventitious root formation in rhododendron microcutting?(SEJANI Ltd., 2014) Dokane, Kristine; Megre, Dace; Lazdane, Madara; Kondratovics, Uldis
- ItemFibronectin-binding nanoparticles for intracellular targeting addressed by B. burgdorferi BBK32 protein fragments(Elsevier, 2013-01) Ranka, Renate; Petrovskis, Ivars; Sominskaya, Irina; Bogans, Janis; Bruvere, Ruta; Akopjana, Inara; Ose, Velta; Timofejeva, Irena; Brangulis, Kalvis; Pumpens, Pauls; Baumanis, ViestursVirus-like particles (VLPs) are created by the self-assembly of multiple copies of envelope and/or capsid proteins from many viruses, mimicking the conformation of a native virus. Such noninfectious nanostructures are mainly used as antigen-presenting platforms, especially in vaccine research; however, some of them recently were used as scaffolds in biotechnology to produce targeted nanoparticles for intracellular delivery. This study demonstrates the creation of fusion VLPs using hepatitis B core protein-based system maintaining a fibronectin-binding property from B. burgdorferi BBK32 protein, including the evidence of particles’ transmission to BHK-21 target cells via caveolae/rafts endocythosis. These results make this construct to be an attractive model in development of HBc-based nanoparticles for cellular targeting applications and highlights the fragment of B. burgdorferi BBK32 as a novel cellular uptake-promoting peptide.
- ItemImpact of Green Manure and Vermicompost on Soil Suppressiveness, Soil Microbial Populations, and Plant Growth in Conditions of Organic Agriculture of Northern Temperate Climate(Springer, 2015) Grantina-Ievina, L.; Nikolajeva, V.; Rostoks, N.; Skrabule, I.; Zarina, L.; Pogulis, A.; Ievinsh, G.
- ItemNail fold capillary diameter changes in acute systemic hypoxia(Elsevier, 2014) Paparde, Artūrs; Nēringa-Martinsone, Ketija; Plakane, Līga; Aivars, Juris Imants
- ItemPrimary culture of avian embryonic heart forming region cells to study the regulation of vertebrate early heart morphogenesis by vitamin A(BioMed Central Ltd, 2014) Cakstina, Ieva; Riekstina, Una; Boroduskis, Martins; Nakurte, Ilva; Ancans, Janis; Zile, Maija H.; Muiznieks, Indrikis
- ItemRecovering Genetic Resources of Some Legume Species of Latvian Origin by Plant Tissue Culture(Latvian Academy of Sciences, 2013) Grauda, Dace; Lapiņa, Lita; Jansone, Biruta; Jnsons, Aldis; Rashal, Isaak
- ItemSeasonal dynamics of biomarkers in infaunal clam Macoma balthica from the Gulf of Riga (Baltic Sea)(Elsevier, 2014) Barda, Ieva; Purina, Ingrida; Rimsa, Elina; Balode, Maija
- ItemSediment quality of the ecoregion Engure, Gulf of Riga, assessed by using ecotoxicity tests and biomarker responses(Latvian Academy of Sciences, 2014) Putna, Ieva; Strode, Evita; Bārda, Ieva; Puriņa, Ingrīda; Rimša, Elīna; Balode, Maija
- ItemSynthesis, physicochemical characterization, cytotoxicity, antimicrobial, anti-inflammatory and psychotropic activity of new N-[1,3-(benzo)thiazol-2-yl]-u-[3,4-dihydroisoquinolin-2(1H)-yl] alkanamides(Elsevier Masson SAS, 2013) Zablotskaya, Alla; Segal, Izolda; Geronikaki, Athina; Eremkina, Tatiana; Belyakov, Sergey; Petrova, Marina; Shestakova, Irina; Zvejniece, Liga; Nikolajeva, Vizma