Medicīnas un dzīvības zinātņu nozaru galvenās publikācijas
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- ItemAssociation of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients(Elsevier, 2013) Skapare, Elina; Konrade, Ilze; Liepinsh, Edgars; Strele, Ieva; Makrecka, Marina; Bierhaus, Angelika; Lejnieks, Aivars; Pirags, Valdis; Dambrova, MaijaAims: The present study was undertaken to investigate the relationship between glyoxalase 1 (Glo1) enzyme activity and painful diabetic neuropathy (DN) in patients with diabetes mellitus. Methods: Glo1 activity and biochemical markers were determined in blood samples from 108 patients with type 1 diabetes, 109 patients with type 2 diabetes, and 132 individuals without diabetes as a control. Painful and painless peripheral DN was assessed and multivariate regression analysis was used to determine independent association of Glo1 activity with occurrence of painful DN. Results: In patients with type 1 and type 2 diabetes mellitus and painful DN compared to patients with painless DN, Glo1 activity was significantly reduced by 12 and 14%, respectively. The increase in Glo1 activity was significantly associated with reduced occurrence of painful DN after adjusting for confounders by multivariate analysis. Conclusions: Our results demonstrate for the first time that Glo1 activity is lower in patients with both types of diabetes mellitus who were diagnosed with painful DN. These data support the hypothesis that Glo1 activity modulates the phenotype of DN and warrant further investigation into the role of Glo1 in DN. © 2013 Elsevier Inc. All rights reserved.
- ItemAtherosclerotic Plaque Characteristics by CT Angiography Identify Coronary Lesions That Cause Ischemia A Direct Comparison to Fractional Flow Reserve(Elsevier, 2015) Park, Hyung-Bok; Heo, Ran; Hartaigh, Bríain; Cho, Iksung; Gransar, Heidi; Nakazato, Ryo; Leipsic, Jonathon; Mancini, John; Koo, Bon-Kwon; Otake, Hiromasa; Budoff, Matthew J.; Berman, Daniel S.; Erglis, Andrejs; Chang, Hyuk-Jae; Min, James K.
- ItemBreath testing as a method for detecting lung cancer(Taylor&Francis, 2014) Taivans, Immanuels; Bukovskis, Maris; Strazda, Gunta; Jurka, NormundsEarly diagnosis of lung cancer is important due to high mortality in late stages of the disease. An ideal approach for population screening could be the breath analysis, due to its non-invasiveness, simplicity and cheapness. Using sensitive methods of analysis like gas chromatography/mass spectrometry in exhaled air of cancer patients were discovered some volatile organic compounds – possible candidates for cancer markers. However, these compounds were not specific for cancer cells. At the same time, integrative approaches used to analyze the exhaled breath have demonstrated high sensitivity and specificity of this method for lung cancer diagnosis. Such integrative approaches include detection of smell prints by electronic nose or integrated analysis of wide range of volatile organic compounds detected by gas chromatography/mass spectrometry or related methods. Modern statistical pattern recognition systems like logistic regression analysis, support vector machine or analysis by artificial neuronal network may improve diagnostic accuracy.
- ItemBreath testing as potential colorectal cancer screening tool(International Union against Cancer, Wiley, 2015) Amal, Haitham; Leja, Marcis; Funka, Konrads; Lasina, Ieva; Skapars, Roberts; Sivins, Armands; Ancans, Guntis; Kikuste, Ilze; Vanags, Aigars; Tolmanis, Ivars; Kirsners, Arnis; Kupcinskas, Limas; Haick, Hossam
- ItemCan changes in starch content and peroxidase activity be used as rooting phase markers for rhododendron leaf bud cuttings?(Polish Academy of Sciences Publishing House, 2011) Megre, Dace; Dokane, Kristine; Kondratovics, Uldis
- ItemCarnitine congener mildronate protects against stress- and haloperidol-induced impairment in memory and brain protein expression in rats(Elsevier, 2014) Beitnere, Ulrika; Dzirkale, Zane; Isajevs, Sergejs; Rumaks, Juris; Svirskis, Simons; Klusa, VijaThe present study investigates the efficacy of mildronate, a carnitine congener, to protect stress and haloperidol-induced impairment of memory in rats and the expression of brain protein biomarkers involved in synaptic plasticity, such as brain-derived neurotrophic factor (BDNF), acetylcholine esterase and glutamate decarboxylase 67 (GAD67). Two amnesia models were used: 2 h immobilization stress and 3-week haloperidol treatment. Stress caused memory impairment in the passive avoidance test and induced a significant 2-fold BDNF elevation in hippocampal and striatal tissues that was completely inhibited by mildronate. Mildronate decreased the level of GAD67 (but not acetylcholine esterase) expression by stress. Haloperidol decrease by a third hippocampal BDNF and acetylcholine esterase (but not GAD67) expression, which was normalized by mildronate; it also reversed the haloperidol-induced memory impairment in Barnes test. The results suggest the usefulness of mildronate as protector against neuronal disturbances caused by stress or haloperidol.
- ItemA common promoter variant of the gene encoding cyclooxygenase-1 (PTGS1) is related to decreased incidence ofmyocardial infarction in patients with coronary artery disease(Elsevier, 2011) Latkovskis, Gustavs; Licis, Normunds; Krivmane, Baiba; Erglis, AndrejsCyclooxigenase (COX)-1, formally known as prostanglandin endoperoxideH synthetase-1,mediates synthesis of prostaglandin H2,which is subsequently converted to various biologically active metabolites including thromboxane (TX) A2 [1]. TXA2 is synthesized and released by activated platelets and strongly reinforces thrombus formation, a critical pathway in the pathogenesis of myocardial infarction (MI). Inhibition of COX-1-derived TXA2 in platelets by low-dose aspirin administration reduces incidence of MI [2]. Hypothetically, MI-risk could also be modified by genetic variants that affect activity or expression of COX-1. Many single nucleotide polymorphisms (SNP) in the gene encoding COX-1 (PTGS1) have been described; including functional alterations in both coding and non-coding regions [3,4].We have evaluated if two of such variations are related to the risk ofMI in a historic cohort of patients with coronary artery disease (CAD).
- ItemComparison of telomere length between population-specificmitochondrial haplogroups among different age groupsin a Latvian population(Elsevier, 2015) Elferts, Didzis; Zole, Egija; Ķimsis, Jānis; Krūmiņa, Astrīda; Narels, Kristaps; Pole, Ilva; Ranka, Renāte; Pliss, Liana
- ItemCopper-Catalyzed Intermolecular C–H Amination of (Hetero)arenes via Transient Unsymmetrical λ3-Iodanes(ACS, 2014) Sokolovs, Igors; Lubriks, Dmitrijs; Suna, Edgars
- ItemA cross-sectional survey of urinary iodine status in Latvia(Elsevier, 2014) Konrade, Ilze; Neimane, Lolita; Makrecka, Marina; Strele, Ieva; Liepinsh, Edgars; Lejnieks, Aivars; Vevere, Parsla; Gruntmanis, Ugis; Pīrāgs, Valdis; Dambrova, Maija
- ItemCrystal structures of the Erp protein family members ErpP and ErpC from Borrelia burgdorferi reveal the reason for different affinities for complement regulator factor H(Elsevier, 2015) Brangulis, Kalvis; Petrovskis, Ivars; Kazaks, Andris; Akopjana, Inara; Tars, KasparsBorrelia burgdorferi is the causative agent of Lyme disease, which can be acquired after the bite of an infected Ixodes tick. As a strategy to resist the innate immunity and to successfully spread and proliferate, B. burgdorferi expresses a set of outermembrane proteins that are capable of binding complement regulator factorH(CFH), factor H-like protein 1 (CFHL-1) and factor H-related proteins (CFHR) to avoid complement-mediated killing. B. burgdorferi B31 contains three proteins that belong to the Erp (OspE/F-related) protein family and are capable of binding CFH and some CFHRs, namely ErpA, ErpC and ErpP. We have determined the crystal structure of ErpP at 2.53 Å resolution and the crystal structure of ErpC at 2.15 Å resolution. Recently, the crystal structure of the Erp familymember OspE fromB. burgdorferi N40was determined in complexwith CFH domains 19–20, revealing the residues involved in the complex formation. Despite the high sequence conservation between ErpA, ErpC, ErpP and the homologous protein OspE (78–80%), the affinity for CFH and CFHRs differsmarkedly among the Erp family members, suggesting that ErpC may bind only CFHRs but not CFH. A comparison of the binding site in OspE with those of ErpC and ErpP revealed that the extended loop region,which is only observed in the potential binding site of ErpC, plays an important role by preventing the binding of CFH. These results can explain the inability of ErpC to bind CFH, whereas ErpP and ErpA still possess the ability to bind CFH.
- ItemDetection of precancerous gastric lesions and gastric cancer through exhaled breath(British Society of Gastroenterology, 2015) Amal, Haitham; Leja, Marcis; Funka, Konrads; Skapars, Roberts; Sivins, Armands; Ancans, Guntis; Liepniece-Karele, Inta; Kikuste, Ilze; Lasina, Ieva; Haick, Hossam
- ItemDNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells(Taylor&Francis, 2013) Jackson, Thomas R.; Salmina, Kristine; Huna, Anda; Inashkina, Inna; Jankevics, Eriks; Riekstina, Una; Kalnina, Zane; Ivanov, Andrey; Townsend, Paul A .; Cragg, Mark S.; Erenpreisa, Jekaterina
- ItemDNA-binding studies of AV-153, an antimutagenic and DNA repair-stimulating derivative of 1,4-dihydropiridine(Elsevier, 2014) Buraka, E.; Yu-Chian Chen, C.; Gavare, M.; Grube, M.; Makarenkova, G.; Nikolajeva, V.; Bisenieks, I.; Brūvere, I.; Bisenieks, E.; Duburs, G.; Sjakste, N.
- ItemDoes shoot anatomical heterogeneity influence Ex Vitro adventitious root formation in rhododendron microcutting?(SEJANI Ltd., 2014) Dokane, Kristine; Megre, Dace; Lazdane, Madara; Kondratovics, Uldis
- ItemFibronectin-binding nanoparticles for intracellular targeting addressed by B. burgdorferi BBK32 protein fragments(Elsevier, 2013-01) Ranka, Renate; Petrovskis, Ivars; Sominskaya, Irina; Bogans, Janis; Bruvere, Ruta; Akopjana, Inara; Ose, Velta; Timofejeva, Irena; Brangulis, Kalvis; Pumpens, Pauls; Baumanis, ViestursVirus-like particles (VLPs) are created by the self-assembly of multiple copies of envelope and/or capsid proteins from many viruses, mimicking the conformation of a native virus. Such noninfectious nanostructures are mainly used as antigen-presenting platforms, especially in vaccine research; however, some of them recently were used as scaffolds in biotechnology to produce targeted nanoparticles for intracellular delivery. This study demonstrates the creation of fusion VLPs using hepatitis B core protein-based system maintaining a fibronectin-binding property from B. burgdorferi BBK32 protein, including the evidence of particles’ transmission to BHK-21 target cells via caveolae/rafts endocythosis. These results make this construct to be an attractive model in development of HBc-based nanoparticles for cellular targeting applications and highlights the fragment of B. burgdorferi BBK32 as a novel cellular uptake-promoting peptide.
- ItemGrain composition and functional ingredients of barley varieties created in Latvia(DE GRUYTER, 2015) Šterna, Vita; Zute, Sanita; Jākobsone, Ida
- ItemIdentification of somatostatin receptor type 5 gene polymorphisms associated with acromegaly(European Society of Endocrinology, 2011) Ciganoka, Darja; Balcere, Inga; Kapa, Ivo; Peculis, Raitis; Valtere, Andra; Nikitina-Zake, Liene; Lase, Ieva; Schiöth, Helgi B.; Pirags, Valdis; Klovins, Janis
- ItemImpact of Green Manure and Vermicompost on Soil Suppressiveness, Soil Microbial Populations, and Plant Growth in Conditions of Organic Agriculture of Northern Temperate Climate(Springer, 2015) Grantina-Ievina, L.; Nikolajeva, V.; Rostoks, N.; Skrabule, I.; Zarina, L.; Pogulis, A.; Ievinsh, G.
- ItemThe implications of stand composition, age and spatial patterns of forest regions with different ownership type for management optimisation in northern Latvia(Elsevier, 2015) Rendenieks, Zigmārs; Nikodemus, Oļģerts; Brūmelis, Guntis